A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells.

@article{Di2008ALC,
  title={A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells.},
  author={Xudong Di and Linda Yu and Alicia B. Moore and Lysandra Castro and Xi-long Zheng and Tonia L. Hermon and Darlene Dixon},
  journal={Human reproduction},
  year={2008},
  volume={23 8},
  pages={1873-83}
}
BACKGROUND Previously, we found that genistein at low concentrations stimulates the growth of human uterine leiomyoma (LM) cells, but not uterine smooth muscle (myometrial) cells (SMC). The aim of this study was to understand the molecular mechanism whereby genistein causes hyperproliferation of LM cells. METHODS The effects of genistein at 1 microg/ml on LM cells and SMC were evaluated using estrogen response element gene reporter, real-time RT-PCR, western blot, immunoprecipitation and cell… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 63 references

Integration of the extranuclear and nuclear actions of estrogen

ER Levin
Mol Endocrinol • 2005
View 4 Excerpts
Highly Influenced

Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells.

The Journal of clinical endocrinology and metabolism • 2004
View 3 Excerpts
Highly Influenced

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