A low-carbohydrate as compared with a low-fat diet in severe obesity.
@article{Samaha2003ALA, title={A low-carbohydrate as compared with a low-fat diet in severe obesity.}, author={Frederick F. Samaha and Nayyar Iqbal and Prakash Seshadri and Kathryn L. Chicano and Denise A. Daily and Joyce McGrory and Terrence Williams and Monica M Williams and Edward J Gracely and Linda Stern}, journal={The New England journal of medicine}, year={2003}, volume={348 21}, pages={ 2074-81 } }
BACKGROUND
The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed.
METHODS
We randomly assigned 132 severely obese subjects (including 77 blacks and 23 women) with a mean body-mass index of 43 and a high prevalence of diabetes (39 percent) or the metabolic syndrome (43 percent) to a carbohydrate-restricted (low-carbohydrate) diet or a calorie- and fat-restricted (low-fat) diet.
RESULTS
Seventy-nine subjects completed…
1,307 Citations
Effects of low-carbohydrate and low-fat diets: a randomized trial.
- MedicineAnnals of internal medicine
- 2014
The low-carbohydrate diet was more effective for weight loss and cardiovascular risk factor reduction than the low-fat diet and Restricting carbohydrate may be an option for persons seeking to lose weight and reduce cardiovascular risk factors.
A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia ☆
- Medicine, Chemistry
- 2004
[The effects of a low-fat versus a low carbohydrate diet in obese adults].
- MedicineMedicina clinica
- 2009
Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet
- MedicineAnnals of Internal Medicine
- 2010
Successful weight loss can be achieved with either a low-fat or low-carbohydrate diet when coupled with behavioral treatment, and aLow- carbohydrate diet is associated with favorable changes in cardiovascular disease risk factors at 2 years.
Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses.
- MedicineInternational journal of cardiology
- 2006
Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia.
- MedicineThe American journal of clinical nutrition
- 2006
Moderate carbohydrate restriction and weight loss provide equivalent but nonadditive approaches to improving atherogenic dyslipidemia.
The Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial
- MedicineAnnals of Internal Medicine
- 2004
The findings 1 year after randomization to a low-carbohydrate diet versus a high-fat weight loss diet (conventional diet) in severely obese adults with a high prevalence of diabetes or the metabolic syndrome are reported.
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects.
- MedicineJournal of the American College of Cardiology
- 2008
Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men.
- MedicineThe Journal of nutrition
- 2004
The very low-carbohydrate diet was more effective at improving characteristics of the metabolic syndrome as shown by a decrease in fasting serum TAG, the TAG/HDL-C ratio, postprandial lipemia, serum glucose, an increase in LDL particle size, and also greater weight loss.
Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo.
- MedicineThe American journal of clinical nutrition
- 2009
Under planned isoenergetic conditions, as expected, both dietary patterns resulted in similar weight loss and changes in body composition and the LC diet may offer clinical benefits to obese persons with insulin resistance.
References
SHOWING 1-10 OF 21 REFERENCES
Effect of 6-month adherence to a very low carbohydrate diet program.
- MedicineThe American journal of medicine
- 2002
Popular diets: correlation to health, nutrition, and obesity.
- MedicineJournal of the American Dietetic Association
- 2001
Dietary Protein and Weight Reduction
- Medicine
- 2001
High-protein diets have recently been proposed as a “new” strategy for successful weight loss, but there are no long-term scientific studies to support their overall efficacy and safety and individuals who follow these diets are at risk for compromised vitamin and mineral intake.
A Review of Very Low Carbohydrate Diets for Weight Loss
- Medicine
- 1999
There is some evidence that very low carbohydrate diets can lead to significant metabolic changes including weight loss, but the long-term risks and benefits are not established, and further research is in order.
Dietary protein and weight reduction: a statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
- MedicineCirculation
- 2001
High-protein diets are not recommended because they restrict healthful foods that provide essential nutrients and do not provide the variety of foods needed to adequately meet nutritional needs, and individuals who follow these diets are therefore at risk for compromised vitamin and mineral intake.
Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease.
- MedicineThe American journal of cardiology
- 2002
Coronary Heart Disease in Patients With Low LDL-Cholesterol: Benefit of Pravastatin in Diabetics and Enhanced Role for HDL-Cholesterol and Triglycerides as Risk Factors
- MedicineCirculation
- 2002
Pravastatin reduced the event rate in diabetics to that of nondiabetic participants, and the results suggest enhanced therapeutic potential for improving HDL-C and triglycerides in patients with CHD who have low LDL-C concentrations.
GEMFIBROZIL FOR THE SECONDARY PREVENTION OF CORONARY HEART DISEASE IN MEN WITH LOW LEVELS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL
- Medicine
- 2000
Gemfibrozil therapy resulted in a significant reduction in the risk of major cardiovascular events in patients with coronary disease whose primary lipid abnormality was a low HDL cholesterol level, suggesting that the rate of coronary events is reduced by raising HDL cholesterol levels and lowering levels of triglycerides without lowering LDL cholesterol levels.
Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group.
- MedicineThe New England journal of medicine
- 1999
Gemfibrozil therapy resulted in a significant reduction in the risk of major cardiovascular events in patients with coronary disease whose primary lipid abnormality was a low HDL cholesterol level, suggesting that the rate of coronary events is reduced by raising HDL cholesterol levels and lowering levels of triglycerides without lowering LDL cholesterol levels.