A low-affinity antagonist reveals saturation and desensitization in mature synapses in the auditory brain stem.

@article{Chanda2010ALA,
  title={A low-affinity antagonist reveals saturation and desensitization in mature synapses in the auditory brain stem.},
  author={Soham Chanda and Matthew A. Xu-Friedman},
  journal={Journal of neurophysiology},
  year={2010},
  volume={103 4},
  pages={1915-26}
}
Postsynaptic receptor desensitization has been observed to contribute to depression in immature synapses. However, it is not clear whether desensitization persists and causes depression in mature synapses. We investigate this issue at the endbulb of Held, the synapse made by auditory nerve (AN) fibers onto bushy cells (BCs) of the anteroventral cochlear nucleus, where depression could influence the processing of sound information. Experiments using cyclothiazide (CTZ) have implicated… CONTINUE READING

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