A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells.

@article{Fu2004ALO,
  title={A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells.},
  author={Vivian X. Fu and Steven R. Schwarze and Michelle L Kenowski and Scott E Leblanc and John Svaren and David Frasier Jarrard},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 50},
  pages={52218-26}
}
The imprinted insulin-like growth factor-2 (IGF2) gene is an auto/paracrine growth factor expressed only from the paternal allele in adult tissues. In tissues susceptible to aging-related cancers, including the prostate, a relaxation of IGF2 imprinting is found, suggesting a permissive role for epigenetic alterations in cancer development. To determine whether IGF2 imprinting is altered in cellular aging and senescence, human prostate epithelial and urothelial cells were passaged serially in… CONTINUE READING
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Loss of IGF2 Imprinting in Senescence 52226 by gest on July 13

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