A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.


The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity mapped to the LOX-PP domain, which… (More)
DOI: 10.1158/0008-5472.CAN-08-4818


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