A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19).

@article{Toda2001ALO,
  title={A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19).},
  author={Katsumi Toda and Toshiji Saibara and Teruhiko Okada and Shinsuke Onishi and Yutaka Shizuta},
  journal={The Journal of endocrinology},
  year={2001},
  volume={168 2},
  pages={217-20}
}
Aromatase P450 (CYP19) is an enzyme responsible for conversion of androgens to oestrogens. We generated CYP19 knockout (ArKO) mice by targeting disruption of the CYP19 gene and observed that the ArKO males exhibited a complete loss of aggressive behaviour against intruder mice when examined using a resident-intruder paradigm. The defect in the behaviour of ArKO males was reinstated when the mice received supplements of 17beta-oestradiol soon after birth. Nevertheless, the cumulative duration of… CONTINUE READING