A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS

@article{Turner2006ALS,
  title={A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS},
  author={Claire Turner and Patrik {\vS}paněl and David Smith},
  journal={Physiological Measurement},
  year={2006},
  volume={27},
  pages={637 - 648}
}
Selected ion flow tube mass spectrometry, SIFT-MS, has been used to monitor the volatile compounds in the exhaled breath of 30 volunteers (19 male, 11 female) over a six-month period. Volunteers provided breath samples each week between 8:45 am and 1 pm (before lunch), and the concentrations of several trace compounds were obtained. In this paper the focus is on methanol in breath. The median methanol level determined using the H3O+ precursor ions for all samples was 461 parts-per-billion (ppb… 

Volatile metabolites in the exhaled breath of healthy volunteers: their levels and distributions

TLDR
The promise of breath analysis as a valuable addition to the tools for clinical diagnosis and therapeutic monitoring is revealed, with the first well-defined concentration distributions of breath metabolites obtained.

Concentrations of some metabolites in the breath of healthy children aged 7–18 years measured using selected ion flow tube mass spectrometry (SIFT-MS)

TLDR
The median ammonia levels in mouth-exhaled breath of these children decreased with age, whereas in older adults, ammonia has been shown to increase with age.

An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry.

TLDR
Breath and skin acetone also clearly change with blood glucose and further work may ultimately enable inferences to be drawn of the blood glucose concentration from skin or breath measurements in type 1 diabetes.

The concentration distributions of some metabolites in the exhaled breath of young adults

TLDR
There is a clear separation in the median breath ethanol levels between those volunteers who had ingested sugary food/drinks and those who had not, which shows that the median levels of these compounds are lower in the young adult volunteer cohort.

Investigation of C3–C10 aldehydes in the exhaled breath of healthy subjects using selected ion flow tube-mass spectrometry (SIFT-MS)

Aldehydes have attracted great scientific and clinical interest as potential disease biomarkers. We have investigated selected ion flow tube-mass spectrometry (SIFT-MS) in detecting and quantifying

Kinetics of ethanol decay in mouth- and nose-exhaled breath measured on-line by selected ion flow tube mass spectrometry following varying doses of alcohol.

TLDR
The detailed results of the analyses of nose-exhaled breath show that the peak levels and the decay rates of breath ethanol are dependent on the ethanol dose and the volume of ethanol/water mixture ingested.

Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry

TLDR
The preliminary results suggest a different origin in the respiratory tract for these two gasses, and standardisation of exhaled VOC measurements is mandatory.

Increase of methanol in exhaled breath quantified by SIFT-MS following aspartame ingestion

TLDR
An ADI dose of aspartame leads to a 3-6 fold increase of blood methanol concentration above the individual baseline values, which agrees quantitatively with a predicted increase of 1030 ppbv estimated using a one-compartment model of uniform dilution of the methanols generated from a known amount of as partame throughout the total body water (including blood).

Rapid in vivo fingerprinting of nonvolatile compounds in breath by extractive electrospray ionization quadrupole time-of-flight mass spectrometry.

TLDR
An extractive electrospray ionization (EESI) quadrupole time-of-flight mass spectrometry (QTOF-MS) method is established without modification of a commercial ESI interface for the rapid in vivo fingerprinting of human breath, presenting a direct way to probe the dynamics of body metabolism and a simple, experimentally convenient method for the fast clinical diagnosis of oral malodors.

Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry

TLDR
The main achievement of the present work is the validated identification of compounds observed in exhaled breath of lung cancer patients, and this identification is indispensible for future work on the biochemical sources of these compounds and their metabolic pathways.
...

References

SHOWING 1-10 OF 32 REFERENCES

A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS

TLDR
The findings indicate the potential value of SIFT-MS as a non-invasive breath analysis technique for investigating volatile compounds in human health and in the diseased state.

A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry.

TLDR
The data relating to healthy individuals are a prelude to using breath analysis for clinical diagnosis, for example, the recognition of bacterial overload in the gut (ethanol) or the possibly of detecting tumours in the body (acetaldehyde).

A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS)

TLDR
Differences in isoprene levels were not directly correlated to gender, age or body mass index, and the range of values for breath samples given is 0-474 ppb.

Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days.

TLDR
There are no obvious patterns in the distributions of these particular metabolites for these individuals, except that the ammonia levels were greatest in the breath of the two oldest subjects.

On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol.

TLDR
It is suggested that the time delay before the breath ethanol begins to increase is an indicator of the gastric emptying rate, and the rate of decay of ethanol from the breath/blood is related to its rate of metabolism subsequent to its dispersal into the body water.

Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study.

TLDR
This preliminary study indicates that the selected ion flow tube technique may be used to detect changes in the trace gases present in breath and define their concentrations in the fasting and replete state and of particular interest is the biphasic response of the breath ammonia concentration after feeding.

Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis.

TLDR
SIFT-MS studies include breath and urinary headspace studies of metabolites, ethanol metabolism, elevated acetone during ovulation, and exogenous compounds; and urinary infection and the presence of tumors, the influence of dialysis on breath ammonia, acetone, and isoprene, and acetaldehyde released by cancer cells in vitro.

Quantification of ammonia in human breath by the selected ion flow tube analytical method using H30+ and 02+ precursor ions.

TLDR
Data are presented of the alveolar ammonia concentrations in the breath of six healthy volunteers following the ingestion of a liquid protein meal, which show that consistent values are obtained using both H30+ and 02+ precursor ions for chemical ionization.

Uptake and disposition of inhaled methanol vapor in humans.

TLDR
Non-saturated, dose-proportional kinetics of methanol up to 200 ppm for 2 h are indicates, apart from blood and urine, saliva also seems suitable for biomonitoring of meethanol exposure.

Metabolic interaction between endogenous methanol and exogenous ethanol studied in human volunteers by analysis of breath.

TLDR
The results confirm the existence of endogenous methanol in human blood and breath and demonstrate that the concentrations present can rise to abnormally high levels when the body is flooded with exogenous ethanol.