A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology.

@article{Nelson1982ALS,
  title={A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology.},
  author={James F. Nelson and Leda Felicio and Patrick K. Randall and Craig Sims and Caleb E. Finch},
  journal={Biology of reproduction},
  year={1982},
  volume={27 2},
  pages={327-39}
}
Cycle frequency, length, and vaginal cytology were measured longitudinally in three cohorts of singly housed virgin mice staggered across a 3-year interval. The age profiles of these parameters were qualitatively similar, but quantitatively different, among cohorts. Cycle frequency was initially low (Phase I), due to prolonged cycles and late-starting cycles, and did not peak (Phase II) until mice were 3-5 months old. Phase II lasted for 7-10 months, depending on the cohort. Thereafter cycle… CONTINUE READING

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