A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis.

@article{Zivadinov2001ALS,
  title={A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis.},
  author={R Zivadinov and Juraj Sep{\vc}i{\'c} and Davide MD Nasuelli and Roberto de Masi and Luisa Monti Bragadin and Maria Antonietta Tommasi and Sandro Zambito-Marsala and Rebecca Moretti and A Oksana Bratina and Maja Ukmar and Roberto S. Pozzi-mucelli and Attilio Grop and Giuseppe MD Cazzato and Marino MD Zorzon},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2001},
  volume={70 6},
  pages={
          773-80
        }
}
OBJECTIVE (a) To establish whether the cognitive decline of the early phase of relapsing-remitting multiple sclerosis depends on the progression of the burden of disease, or on the loss of brain parenchyma, or is influenced by both; (b) to monitor the loss of brain parenchyma in the early phase of the disease; and (c) to examine its possible relation with the progression of physical disability. METHODS For 2 years 53 patients with clinically definite relapsing-remitting multiple sclerosis… CONTINUE READING

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