A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate.

@article{Romero2008ALS,
  title={A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate.},
  author={Roberto Romero and Jyh Kae Nien and Jimmy Espinoza and David Todem and Wenjiang Fu and Hwan Chung and Juan Pedro Kusanovic and Francesca Gotsch and Offer Erez and Shali Mazaki-Tovi and Ricardo Pay{\'a}n Gom{\'e}z and Sam S Edwin and Tinnakorn Chaiworapongsa and Richard J. Levine and Siddharth Karumanchi},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2008},
  volume={21 1},
  pages={9-23}
}
INTRODUCTION Accumulating evidence suggests that an imbalance between pro-angiogenic (i.e., vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)) and anti-angiogenic factors (i.e., soluble VEGF receptor-1 (sVEGFR-1, also referred to as sFlt1)) is involved in the pathophysiology of preeclampsia (PE). Endoglin is a protein that regulates the pro-angiogenic effects of transforming growth factor beta, and its soluble form has recently been implicated in the pathophysiology… CONTINUE READING
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