A longitudinal analysis of pulmonary function in rats during a 12 month cigarette smoke exposure.

@article{Wright1997ALA,
  title={A longitudinal analysis of pulmonary function in rats during a 12 month cigarette smoke exposure.},
  author={Joanne L. Wright and Jun Ping Sun and Sverre Vedal},
  journal={The European respiratory journal},
  year={1997},
  volume={10 5},
  pages={
          1115-9
        }
}
We wanted to examine the longitudinal effects of chronic cigarette smoke exposure, and to determine whether the chronic alterations in pulmonary function induced by long-term cigarette smoke exposure in an animal model could be predicted by initial or early alterations in function. A group of Sprague Dawley rats was exposed to the smoke of 7 cigarettes x day(-1) for 5 days x week(-1) during a total period of 12 months. Lung volume, flow-volume curves and pressure-volume curves were recorded at… CONTINUE READING

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