A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B.

@article{Tan2010ALA,
  title={A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B.},
  author={A. T. Tan and S. N. Koh and Winnie Goh and Heng Yee Zhe and Adam J. Gehring and Seng Gee Lim and Antonio Bertoletti},
  journal={Journal of hepatology},
  year={2010},
  volume={52 3},
  pages={330-9}
}
BACKGROUND & AIMS The pathogenesis of hepatic flares (HF) in patients chronically infected with hepatitis B virus (HBV) is controversial. Therefore, we studied the kinetics of innate and adaptive immune activation during HF in chronic hepatitis B. METHODS Soluble (IFN-alpha, IL-1beta, TNF-alpha, IL-6, IL-8, IL-10, CCL-2, CCL-3, CXCL-9, CXCL-10) and cellular (HBV-specific T cells, NK, Treg) immunological parameters were measured longitudinally (10 month-4 week intervals) in patients (n=5) who… CONTINUE READING