A longitudinal analysis of cytotoxic T lymphocyte precursor frequencies to the hepatitis B virus in chronically infected patients.

Abstract

Individuals with acute hepatitis B virus (HBV) infection characteristically mount a strong, multispecific cytotoxic T lymphocyte (CTL) response that is effective in eradicating virus. In contrast, this response in chronic carriers is usually weak or undetectable. Since it is generally acknowledged that HBV pathogenesis is immune-mediated, the occurrence of… (More)

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@article{Sing2001ALA, title={A longitudinal analysis of cytotoxic T lymphocyte precursor frequencies to the hepatitis B virus in chronically infected patients.}, author={Garwin K. Sing and Andrew Ladhams and S. Arnold and Hemant A. Parmar and X. Chen and Jennifer Cooper and Lori Butterworth and Kirsty Stuart and Deirdre M D'arcy and William Graham Earnshaw Cooksley}, journal={Journal of viral hepatitis}, year={2001}, volume={8 1}, pages={19-29} }