A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder.

@article{Matsunaga2009ALT,
  title={A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder.},
  author={Hisato Matsunaga and Toshihiko Nagata and Kazuhisa Hayashida and Kenzo Ohya and Nobuo Kiriike and D. J. Stein},
  journal={The Journal of clinical psychiatry},
  year={2009},
  volume={70 6},
  pages={
          863-8
        }
}
OBJECTIVE Although atypical antipsychotic agents have been found effective in the augmentation of serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in short-term trials, there are few data on the effectiveness and safety of these agents in clinical settings over the long term. METHOD Subjects (N = 46) who responded to selective SRIs (SSRIs) in an initial 12-week trial were continued on SSRI monotherapy plus cognitive-behavioral therapy (CBT) for… CONTINUE READING

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