A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group.

@article{Tsakonas1998ALS,
  title={A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group.},
  author={Eva Tsakonas and Lawrence Joseph and John M. Esdaile and Denis Choquette and J. L. Senecal and Alfred A Cividino and Deborah Danoff and Carsten Osterland and Christopher Yeadon and Charles D Smith},
  journal={Lupus},
  year={1998},
  volume={7 2},
  pages={
          80-5
        }
}
The ability of antimalarials to moderate severe disease activity in systemic lupus erythematosus (SLE) is plausible but undemonstrated. We evaluated the long-term effectiveness of maintaining treatment with hydroxychloroquine sulphate (HCQ) to prevent major flares in quiescent SLE. Forty-seven patients with quiescent SLE who had been randomized to take HCQ (n = 25) or placebo (n = 22) as part of a 24-week withdrawal trial were evaluated for an additional 3 years. The primary outcome was time to… CONTINUE READING
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