A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice.

@article{Brown2000ALH,
  title={A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice.},
  author={Jennifer J. Brown and B. S. Nagendra Parashar and Han Moshage and K. O. Tanaka and Dean Engelhardt and Elazar Rabbani and Namita Roy-Chowdhury and Jayanta Roy-Chowdhury},
  journal={Hepatology},
  year={2000},
  volume={31 1},
  pages={173-81}
}
Development of new therapies for human hepatitis B virus infection (HBV) would be greatly facilitated by the availability of a suitable small-animal model for HBV virus production in vivo. To develop a murine model for HBV production, we established an immortalized, cloned liver cell line by transferring the Simian Virus 40 Large T-Antigen into primary human hepatocytes. These cells were stably transfected with a full-length HBV genome to generate a clone that expresses HBV genes and replicates… CONTINUE READING

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