A long-term dose-response study of mitomycin in glaucoma filtration surgery.

  title={A long-term dose-response study of mitomycin in glaucoma filtration surgery.},
  author={Alan L. Robin and Rengappa Ramakrishnan and Ramasamy Krishnadas and Scott D. Smith and Joshua D Katz and Sivasubramaniam Selvaraj and Gregory L Skuta and Rishi Bhatnagar},
  journal={Archives of ophthalmology},
  volume={115 8},
OBJECTIVE To establish the long-term, dose-response relationship between the concentration of and duration of exposure to mitomycin to a decrease in intraocular pressure (IOP) and fewer complications. METHODS We performed a prospective double-masked, placebo-controlled, 1-year study evaluating the decrease in IOP and fewer complications of fornix-based trabeculectomy surgery in 300 eyes equally divided among therapy with placebo; mitomycin, 0.2 mg/ mL, applied for 2 minutes; mitomycin, 0.4 mg… CONTINUE READING

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