A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.

@article{Hou2014ALN,
  title={A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.},
  author={Zhibo Hou and Wei Zhao and Ji Zhou and L. R. Shen and Ping Zhan and Chunhua Xu and Cunjie Chang and Hui Bi and Jue Zou and Xin Yao and Ruimin Huang and Like Yu and Jun Biao Yan},
  journal={The international journal of biochemistry & cell biology},
  year={2014},
  volume={53},
  pages={380-8}
}
Sox2 overlapping transcript (Sox2ot) is a long noncoding RNA (lncRNA), localized on human chromosome 3q26.33, which is frequently amplified in lung squamous cell carcinomas (SCCs). However, its roles in lung cancer remain under investigation. In this study, we found that Sox2ot was up-regulated over two folds in 53.01% of human primary lung cancers (44/83). The expression level of Sox2ot is significantly higher in SCCs than that in adenocarcinomas (ADCs) of the lung. Further study found high… CONTINUE READING
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