A long helix from the central region of smooth muscle caldesmon.

@article{Wang1991ALH,
  title={A long helix from the central region of smooth muscle caldesmon.},
  author={C L-Albert Wang and Joseph M Chalovich and Philip Graceffa and Renne Chen Lu and Katsuhide Mabuchi and Walter F. Stafford},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 21},
  pages={13958-63}
}
The central region of smooth muscle caldesmon is predicted to form alpha-helices on the basis of its primary structure. We have isolated a fragment (CT54) that contains this region. The hydrodynamic properties and the electron microscopic images suggest that CT54 is an elongated (35 nm), monomeric molecule. The circular dichroic spectrum yields an overall alpha-helical content of 55-58%. These results are consistent with the model that the middle portion of CT54 forms a long stretch of single… CONTINUE READING