A long, remarkable journey: Tangential migration in the telencephalon

  title={A long, remarkable journey: Tangential migration in the telencephalon},
  author={Oscar Mar{\'i}n and John L. R. Rubenstein},
  journal={Nature Reviews Neuroscience},
Recent studies on the origin of cell populations in rodent and chicken embryonic brains provide evidence for extensive tangential migration within the developing telencephalon. On the basis of these findings, a new concept of corticogenesis has emerged, which proposes that two distinct neuronal populations cooperate in the formation of the cortex. One population consists of radially migrating neurons that originate in the ventricular zone of the pallium (cortex) and give rise to the… 
REVIEW ARTICLE: Neurotransmitters regulate cell migration in the telencephalon
A review summarizes and discusses the growing body of literature implicating neurotransmitters and their cognate receptors as part of a complex molecular machinery that regulate the migration of immature neurons in the telencephalon during development and in adulthood.
Neuronal migration and the role of reelin during early development of the cerebral cortex
Three aspects are placed on the role of the actin treadmill, with cyclic formation of filopodial and lamellipodial extensions, in relation to surface events that occur at the leading edge of radially migrating neurons; the regulation of microtubule dynamics, which seems to play a key role in nucleokinesis; and the mechanisms by which the extracellular protein Reelin regulates neuronal positioning at the end of migration.
Origin and Migration of Olfactory Cajal-Retzius Cells
A novel olfactory CR cell migration is revealed and the idea that the ventral pallium, where diverse types of neurons converge, does not actually generate CR cells is supported.
Evidences for tangential migrations in Xenopus telencephalon: Developmental patterns and cell tracking experiments
The findings strongly suggest that the developing Xenopus telencephalon shares many similarities with amniotes in terms of neuronal specification and migrations, however, some differences are discussed, particularly with regard to the evolution of the pallium.
Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex
Time-lapse imaging and in vivo labelling indicated that MZ cortical interneurons undergo a second phase of tangential migration in all directions and over long distances, after reaching the cortex by dorsomedial tangential Migration.
Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System
It is shown that Pax6 (paired box gene 6)-positive pallial-derived and Dlx2 (distal-less homeobox 2)-positive subpallial- derived subpopulations of LCS cells are generated in distinct temporal windows during embryogenesis, and the generation of the LCS is dependent on the homeodomain-containing gene Gsh2, revealing a novel requirement for GSh2 in telencephalic development.
Four-Dimensional Migratory Coordinates of GABAergic Interneurons in the Developing Mouse Cortex
Time-lapse multiphoton microscopy is used to map the migration and settling pattern of GABAergic interneurons that originate in the ganglionic eminence of the ventral forebrain and incorporate into the neocortex of the cerebral hemispheres, suggesting that interneuron have specific programs for their areal and laminar deployment.
The different modes of migration that are adopted by neurons of the mammalian cerebral cortex are discussed, their underlying cellular and molecular mechanisms, and the significance of the various modes in building this complex structure are discussed.
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by
Rostro-Caudal and Caudo-Rostral Migrations in the Telencephalon: Going Forward or Backward?
An overview of the developmental origin of the different telencephalic subdivisions and a description of migratory pathways taken by distinct neural populations traveling long distances before reaching their target position in the brain are presented.


The avian telencephalic subpallium originates inhibitory neurons that invade tangentially the pallium (dorsal ventricular ridge and cortical areas).
The results suggest that the telencephalon of birds and mammals share developmental mechanisms for the origin and migration of their cortical interneurons, which probably first evolved at an earlier stage in the radiation of vertebrates than was thought before.
Early-generated preplate neurons in the developing telencephalon: inward migration into the developing striatum.
An unexpected evidence is disclosed that a subset of early-generated neurons of the piriform preplate migrate inward into and disperse within the subcortical structure striatum during the embryonic stage.
Telencephalic origin of human thalamic GABAergic neurons
Modifications in the pattern of migratory guidance cues in the forebrain may underlie the appearance of a new migratory pathway and thus contribute to the evolutionary expansion of the thalamic association nuclei in the human.
Tangential migration of neurons in the developing cerebral cortex.
Analysis of the orientations of [3H]thymidine-labeled migrating cells suggests that nonradial migration is equally common in brain slices and the intact cortex and that it increases during neurogenesis, and examination of the relationships between migratory cells and axons revealed axonal contacts with both radial and nonradially cells.
Origin and Route of Tangentially Migrating Neurons in the Developing Neocortical Intermediate Zone
The majority of tangentially migrating cells were generated in the lateral ganglionic eminence of the LGE and identified as a distinct population that was assumed not to have joined the cortical plate.
Central nervous system neuronal migration.
  • M. Hatten
  • Biology
    Annual review of neuroscience
  • 1999
Molecular analysis of the genes that mark stages of secondary neurogenesis show similar expression patterns of a number of genes, so these three regions may have genetic pathways in common and be considered for human brain malformations and neurological mutant mice.
Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat
It is concluded that cells of the primary olfactory cortex derive from the lateral ganglionic eminence and that some early generated cells migrating from the longitudinal eminence transgress the cortico-striatal boundary entering the preplate of the neocortical primordium.
The role of Pax6 in restricting cell migration between developing cortex and basal ganglia.
Dorso-ventral cell migration in the telencephalon of Pax6 mutant mice confirmed that the cortico-striatal boundary acts as a semipermeable filter and allows a proportion of cells from the ganglionic eminence to invade the cortex, but not vice versa.