A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.

@article{Amendola2010ALO,
  title={A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.},
  author={Elena Amendola and Remo Sanges and Antonella Galvan and Nina A Dathan and Giacomo Manenti and Giuseppe Ferrandino and Francesca Maria Alvino and Tina Di Palma and Marzia Scarf{\`o} and Mariastella Zannini and Tommaso A Dragani and Mario De Felice and Roberto Di Lauro},
  journal={Endocrinology},
  year={2010},
  volume={151 4},
  pages={1948-58}
}
We report here the mapping of a chromosomal region responsible for strain-specific development of congenital hypothyroidism in mice heterozygous for null mutations in genes encoding Nkx2-1/Titf1 and Pax8. The two strains showing a differential predisposition to congenital hypothyroidism contain several single-nucleotide polymorphisms in this locus, one of… CONTINUE READING