A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice.

@article{Aherrahrou2004ALO,
  title={A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice.},
  author={Zouhair Aherrahrou and Susanne B Axtner and Piotr Maciel Kaczmarek and Alexandra Jurat and Susanne Korff and Lars Christian Doehring and Dieter Weichenhan and Hugo A. Katus and Boris Tomislav Ivandic},
  journal={The American journal of pathology},
  year={2004},
  volume={164 4},
  pages={1379-87}
}
Calcification of necrotic tissue is frequently observed in chronic inflammation and atherosclerosis. A similar response of myocardium to injury, referred to as dystrophic cardiac calcinosis (DCC), occurs in certain inbred strains of mice. We now examined a putative inhibitor of calcification, osteopontin, in DCC after transdiaphragmal myocardial freeze-thaw injury. Strong osteopontin expression was found co-localizing with calcification in DCC-susceptible strain C3H/HeNCrlBr, which exhibited… CONTINUE READING
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