A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.

@article{Anthoni2007ALO,
  title={A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.},
  author={Heidi Anthoni and Marco Zucchelli and Hans Matsson and Bertram M{\"u}ller-Myhsok and Ingegerd Fransson and Johannes Schumacher and Satu Massinen and P{\"a}ivi Onkamo and Andreas Warnke and Heide Griesemann and Per Hoffmann and Jaana Nopola-Hemmi and Heikki Lyytinen and Gerd Schulte-Koerne and Juha Kere and Markus M. N{\"o}then and Myriam Peyrard-Janvid},
  journal={Human molecular genetics},
  year={2007},
  volume={16 6},
  pages={667-77}
}
DYX3, a locus for dyslexia, resides on chromosome 2p11-p15. We have refined its location on 2p12 to a 157 kb region in two rounds of linkage disequilibrium (LD) mapping in a set of Finnish families. The observed association was replicated in an independent set of 251 German families. Two overlapping risk haplotypes spanning 16 kb were identified in both sample sets separately as well as in a joint analysis. In the German sample set, the odds ratio for the most significantly associated haplotype… CONTINUE READING

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