A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.

@article{Shimizu2004ALF,
  title={A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.},
  author={Satoko Shimizu and Charles M. Krafchak and Nobuo Fuse and Michael P Epstein and Miriam T Schteingart and Alan Sugar and Maya Eibschitz-Tsimhoni and Catherine Allaire Downs and Frank William Rozsa and Edward H. Trager and David M. Reed and Michael Boehnke and Sayoko E. Moroi and Julia E. Richards},
  journal={American journal of medical genetics. Part A},
  year={2004},
  volume={130A 4},
  pages={
          372-7
        }
}
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant disorder characterized by corneal endothelial abnormalities, which can lead to blindness due to loss of corneal transparency and sometimes glaucoma. We mapped a new locus responsible for PPCD in a family in which we excluded the previously reported PPCD locus on 20q11, and the region containing COL8A2 on chromosome 1. Results of a 317-marker genome scan provided significant evidence of linkage of PPCD to markers on… CONTINUE READING
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