A locus for autosomal dominant posterior polar cataract on chromosome 1p.

@article{Ionides1997ALF,
  title={A locus for autosomal dominant posterior polar cataract on chromosome 1p.},
  author={Alexander C W Ionides and V. Berry and D. Scott Mackay and Anthony T Moore and Shomi Shanker Bhattacharya and Alan Shiels},
  journal={Human molecular genetics},
  year={1997},
  volume={6 1},
  pages={47-51}
}
Autosomal dominant congenital cataract is a clinically and genetically heterogeneous lens disease. Here we report the linkage of a locus for autosomal dominant posterior polar cataract (CPP) to the distal short arm of chromosome 1. To map the CPP locus we performed molecular genetic linkage analysis using microsatellite markers in a three-generation pedigree. After exclusion of 13 known loci and candidate lens genes for autosomal dominant cataract, we obtained significantly positive LOD scores… CONTINUE READING

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