A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1.

@article{Jakubowski1999ALH,
  title={A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1.},
  author={Joseph Jakubowski and Kerry Kornfeld},
  journal={Genetics},
  year={1999},
  volume={153 2},
  pages={743-52}
}
Ras-mediated signaling is required for induction of vulval cell fates during Caenorhabditis elegans development. By screening for suppressors of the multivulva phenotype caused by constitutively active let-60 ras, we identified the mutation n2527. To clone the gene affected by n2527, we developed a method for high-resolution mapping. We took advantage of the genomic DNA sequence of the N2 strain by using DNA sequencing to scan for single-nucleotide polymorphisms (SNPs) at defined genomic… CONTINUE READING
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