A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.

@article{Cereghini1988ALF,
  title={A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.},
  author={Silvia Cereghini and M. Blumenfeld and M. Yaniv},
  journal={Genes & development},
  year={1988},
  volume={2 8},
  pages={957-74}
}
We have identified and characterized two mutually exclusive nuclear proteins that interact with a single crucial element of the albumin promoter. One, albumin proximal factor (APF), is found only in liver or differentiated hepatoma cells and is probably identical to the liver-specific factor named HNF1, alpha 1TFB, or HP1-binding protein. The other, variant albumin proximal factor (vAPF), is present in dedifferentiated hepatoma cells as well as in somatic cell hybrids that show extinction of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…