A liver enhancer in the fibrinogen gene cluster.


The plasma concentration of fibrinogen varies in the healthy human population between 1.5 and 3.5 g/L. Understanding the basis of this variability has clinical importance because elevated fibrinogen levels are associated with increased cardiovascular disease risk. To identify novel regulatory elements involved in the control of fibrinogen expression, we… (More)
DOI: 10.1182/blood-2010-07-295410

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