A live vaccine to Staphylococcus aureus infection

@article{Parker2018ALV,
  title={A live vaccine to Staphylococcus aureus infection},
  author={Dane Parker},
  journal={Virulence},
  year={2018},
  volume={9},
  pages={700 - 702}
}
  • D. Parker
  • Published 21 March 2018
  • Medicine, Biology
  • Virulence
In this issue Moscoso et al [1] present exciting data utilizing a D-alanine mutant of Staphylococcus aureus as a live vaccine against lethal infection. Given the absence of a currently approved vaccine and antibiotic resistance within the S. aureus population it provides new hope in the prevention of this common human pathogen. 
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12 Citations

Development of a Conserved Chimeric Vaccine for Induction of Strong Immune Response against Staphylococcus aureus Using Immunoinformatics Approaches

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Subtractive proteomic analysis of antigenic extracellular proteins and design a multi‐epitope vaccine against Staphylococcus aureus

The designed vaccine construct VSA‐30 can be developed as an appropriate vaccine to target S. aureus infection and still needs experimental validation to assure the antigenic and immunogenic properties.

Important new therapies for methicillin-resistant Staphylococcus aureus

The efficacy and safety of recently approved anti-MRSA molecules as well as some newer agents currently under investigation are reviewed with a specific focus on the potential role of these drugs in everyday clinical practice.

Epidemiology of Staphylococcus aureus Infections in Kenya: Current State, Gaps and Opportunities

Standardized national surveillance and reporting incorporating molecular tools for identification and characterization will help fill existing gaps in the understanding of the evolving epidemiology of MRSA infections in Kenya.

Recent developments in methicillin- resistant Staphylococcus aureus (MRSA) management and potential antimicrobial alternatives to combat the antibiotic resistance challenge: A review

A brief description of potential antimicrobial alternatives i.e., phytochemicals from plant extracts, bacteriocins, antimicrobial peptides, bacteriaiophage therapy, nanoparticles and some other approaches that can be used as monotherapy or in combination with currently effective antibiotics to combat MRSA infections are provided.

Identification of CD4+ T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking

A set of 11 CD4+ T cell epitopes that can be used as vaccine candidates was identified on the basis of the analysis of the strength of binding, non-self presentation in the human host, propensity to bind to a higher number of alleles, and energetically favorable interactions with HLA molecules.

Dangerous Pathogens as a Potential Problem for Public Health

This paper is to present the most dangerous pathogens, as well as general characterizations, mechanisms of action, and treatments, among bacteria and viruses that have a significant impact on public health.

A blood-based comprehensive and systems-level analysis of disease stages, immune regulation and symptoms in COVID-19 patients

The study involving PBMC-based RNA profiling may further help understand complex and variable systems-wide responses displayed by coronavirus-infected patients.

Design, synthesis, and discovery of novel oxindoles bearing 3-heterocycles as species-specific and combinatorial agents in eradicating Staphylococcus species

Novel oxindole compounds directly have lethal action or boost existing antibiotic power with the reduction of doses and toxicity in the treatment of multidrug-resistant Staphylococcus species.

A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients

The COVID-engine inferential statistics platform and study involving PBMC-based RNA profiling may help understand complex and variable system-wide responses displayed by coronavirus-infected patients with further validation.

References

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