A live vaccine rapidly protects against cholera in an infant rabbit model

  title={A live vaccine rapidly protects against cholera in an infant rabbit model},
  author={Troy P Hubbard and Gabriel Billings and Tobias D{\"o}rr and Brandon Sit and Alyson R Warr and Carole J Kuehl and Minsik Kim and Fernanda Delgado and John J Mekalanos and Joseph A Lewnard and Matthew K Waldor},
  journal={Science Translational Medicine},
Outbreaks of cholera, a rapidly fatal diarrheal disease, often spread explosively. The efficacy of reactive vaccination campaigns—deploying Vibrio cholerae vaccines during epidemics—is partially limited by the time required for vaccine recipients to develop adaptive immunity. We created HaitiV, a live attenuated cholera vaccine candidate, by deleting diarrheagenic factors from a recent clinical isolate of V. cholerae and incorporating safeguards against vaccine reversion. We demonstrate that… CONTINUE READING

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