A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.

@article{Vallecillo2015ALC,
  title={A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.},
  author={Mar{\'i}a F. S{\'a}nchez Vallecillo and Mar{\'i}a M Minguito de la Escalera and Mar{\'i}a Victoria Fern{\'a}ndez Aguirre and Gabriela V Ullio Gamboa and Santiago Daniel Palma and Leticia Gonz{\'a}lez-Cintado and Ana L. Chiodetti and German Soldano and G Yohandro Mor{\'o}n and Daniel Alberto Allemandi and Carlos X. Ardav{\'i}n and Mar{\'i}a C. Pistoresi-Palencia and Belkys Ang{\'e}lica Maletto},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={214},
  pages={
          12-22
        }
}
Modern subunit vaccines require the development of new adjuvant strategies. Recently, we showed that CpG-ODN formulated with a liquid crystal nanostructure formed by self-assembly of 6-O-ascorbyl palmitate (Coa-ASC16) is an attractive system for promoting an antigen-specific immune response to weak antigens. Here, we showed that after subcutaneous injection of mice with near-infrared fluorescent dye-labeled OVA antigen formulated with Coa-ASC16, the dye-OVA was retained at the injection site… CONTINUE READING
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