A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma.

@article{Lin2009ALC,
  title={A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma.},
  author={S N Lin and Lolita Lamm and Thomas F. Newton and Malcolm S. Reid and David E. Moody and Rodger Foltz},
  journal={Journal of analytical toxicology},
  year={2009},
  volume={33 5},
  pages={237-42}
}
A rugged liquid chromatographic-electrospray ionization-tandem mass spectrometric (LC-ESI-MS-MS) method was developed and validated for accurate monitoring of steady-state plasma aripiprazole. Haloperidol-d(4) was chosen as the internal standard. ESI of aripiprazole and haloperidol-d(4) yielded abundant MH(+) ions, m/z 448 and 379, respectively. These ions were collision-dissociated to respective product ions of m/z 285 and 168. Ion-suppression experiments with blank plasma extracts showed… CONTINUE READING

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