A lipoxygenase inhibitor in breast cancer brain metastases

@article{Flavin2006ALI,
  title={A lipoxygenase inhibitor in breast cancer brain metastases},
  author={Dana F. Flavin},
  journal={Journal of Neuro-Oncology},
  year={2006},
  volume={82},
  pages={91-93}
}
The complication of multiple brain metastases in breast cancer patients is a life threatening condition with limited success following standard therapies. The arachidonate lipoxygenase pathway appears to play a role in brain tumor growth as well as inhibition of apoptosis in in-vitro studies. The down regulation of these arachidonate lipoxygenase growth stimulating products therefore appeared to be a worthwile consideration for testing in brain metastases not responding to standard therapy… CONTINUE READING
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5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2008
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