A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis

@article{Reymer1995ALL,
  title={A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis},
  author={Paul W.A. Reymer and Eric Gagn{\'e} and Bjorn E. Groenemeyer and Hanfang Zhang and Ian Forsyth and Hans G. P. Jansen and Jacob C. Seidell and Daan Kromhout and Kong E. Lie and Johannes Kastelein and Michael R. Hayden},
  journal={Nature Genetics},
  year={1995},
  volume={10},
  pages={28-34}
}
A reduction of high density lipoprotein cholesterol (HOC) is recognized as an important risk factor for coronary artery disease (CAD). We now show in approximately 1 in 20 males with proven atherosclerosis that an Asn291Ser mutation in the human lipoprotein lipase (LPL) gene is associated with significantly reduced HDL levels (P=0.001) and results in a significant decrease in LPL catalytic activity (P<0.0009). The relative frequency of this mutation increases in those patients with lower HDL… CONTINUE READING

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