A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication.

@article{Cruikshank1997ALA,
  title={A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication.},
  author={William W. Cruikshank and Susan R. Doctrow and Michael Falvo and Karl D. Huffman and Janusz Maciaszek and Gregory A. Viglianti and Jay Raina and Hardy Kornfeld and B. Malfroy},
  journal={Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association},
  year={1997},
  volume={14 3},
  pages={193-203}
}
We have developed a chemical modification of antibodies, lipidation, which enables their intracellular delivery into living cells. Intracellular localization of lipidated antibodies was demonstrated by confocal microscopy and by measuring cellular uptake of 125I-labeled lipidated antibodies. Functionally, a lipidated monoclonal antibody directed against the… CONTINUE READING