• Corpus ID: 248665603

A lipid-structured mathematical model of atherosclerosis with macrophage proliferation

  title={A lipid-structured mathematical model of atherosclerosis with macrophage proliferation},
  author={Keith L Chambers and Michael G. Watson and Mary R. Myerscough},
We extend the lipid-structured model for atherosclerotic plaque development of Ford et al (2019) to account for macrophage proliferation. Proliferation is modelled as a non-local decrease in the lipid structural variable that is similar to the treatment of cell division in size-structured models (e.g. Efendiev et al (2018)). Steady state analysis indicates that proliferation assists in reducing eventual necrotic core size and acts to spread the lipid load of the macrophage population amongst… 

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