A lipid-mediated conformational switch modulates the thermosensing activity of DesK.

Abstract

The thermosensor DesK is a multipass transmembrane histidine-kinase that allows the bacterium Bacillus subtilis to adjust the levels of unsaturated fatty acids required to optimize membrane lipid fluidity. The cytoplasmic catalytic domain of DesK behaves like a kinase at low temperature and like a phosphatase at high temperature. Temperature sensing… (More)
DOI: 10.1073/pnas.1317147111

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