A lipid-dependent uncoupled conformation of the acetylcholine receptor.

  title={A lipid-dependent uncoupled conformation of the acetylcholine receptor.},
  author={Corrie J. B. daCosta and John Baenziger},
  journal={The Journal of biological chemistry},
  volume={284 26},
Lipids influence the ability of Cys-loop receptors to gate open in response to neurotransmitter binding, but the underlying mechanisms are poorly understood. With the nicotinic acetylcholine receptor (nAChR) from Torpedo, current models suggest that lipids modulate the natural equilibrium between resting and desensitized conformations. We show that the lipid-inactivated nAChR is not desensitized, instead it adopts a novel conformation where the allosteric coupling between its neurotransmitter… CONTINUE READING
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