A linkage study of 12 IDDM susceptibility loci in the Finnish population.

Abstract

BACKGROUND HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D development. METHODS We tested 12 of… (More)

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