A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4

@article{Hansen2015ALB,
  title={A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4},
  author={Matilde Thye Hansen and Birgitte Forst and Natascha Cremers and Luca Quagliata and Noona S Ambartsumian and Birgitte Grum-Schwensen and J{\"o}rg Klingelh{\"o}fer and Ahmad Abdul-Al and Pia Herrmann and Marc Osterland and Ulrike Stein and Gitte Helle Nielsen and Phillip E Scherer and E. M. Lukanidin and Jonathan P Sleeman and Mariam Grigorian},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={424-435}
}
S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are transcriptional targets of S100A4 via Toll-like receptor 4 (TLR4)/nuclear factor-κB signaling. SAA proteins stimulated the transcription of RANTES (regulated upon activation normal T-cell expressed and presumably… CONTINUE READING
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