A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2.

@article{Dudler1995ALB,
  title={A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2.},
  author={T Dudler and Denise C. Machado and Lottie Kolbe and R R Annand and Nelson Rhodes and Michael H Gelb and Kersten Kurt Koelsch and Mark Suter and Birgit A. Helm},
  journal={Journal of immunology},
  year={1995},
  volume={155 5},
  pages={2605-13}
}
The molecular and cellular mechanisms controlling Ab isotype selection following encounter of a given Ag are still unclear, although the regulatory role of cytokines is established. In the present study we explored the possibility that the nonimmunologic interaction of an allergen with cells of the innate immune system might result in a release of mediators that promote IgE isotype selection in adaptive responses. Using the bee venom allergen phospholipase A2 (PLA2) and a mutant variant lacking… CONTINUE READING
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