A link between c-Myc-mediated transcriptional repression and neoplastic transformation.

@article{Lee1996ALB,
  title={A link between c-Myc-mediated transcriptional repression and neoplastic transformation.},
  author={Linda A. Lee and Christine E. Dolde and J. F. Barrett and Ching Shu Wu and Chi V. Dang},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 7},
  pages={1687-95}
}
Recent studies indicate that the transcription factor c-Myc contributes to oncogenesis by altering the expression of genes involved in cell proliferation, but its precise function in neoplasia remains ambiguous. The ability of c-Myc to bind the sequence CAC(G/A)TG and transactivate appears to be linked to its transforming activity; however, c-Myc also represses transcription in vitro through a pyrimidine-rich cis element termed the initiator (Inr). In transfection experiments using the… CONTINUE READING

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