A lineage-specific protein kinase crucial for myeloid maturation.

  title={A lineage-specific protein kinase crucial for myeloid maturation.},
  author={Dimitri Semizarov and David Glesne and A. Laouar and Katrin Schiebel and Eliezer Huberman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 26},
To identify genes involved in macrophage development, we used the differential display technique and compared the gene expression profiles for human myeloid HL-60 leukemia cell lines susceptible and resistant to macrophage maturation. We identified a gene coding for a protein kinase, protein kinase X (PRKX), which was expressed in the maturation-susceptible, but not in the resistant, cell line. The expression of the PRKX gene was found to be induced during monocyte, macrophage, and granulocyte… CONTINUE READING
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