A limited sampling strategy for pharmacokinetic directed therapy with intravenous busulfan.

@article{Vaughan2002ALS,
  title={A limited sampling strategy for pharmacokinetic directed therapy with intravenous busulfan.},
  author={William P. Vaughan and Delicia Carey and Stephanie W Perry and Andrew O. Westfall and Donna E. Salzman},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2002},
  volume={8 11},
  pages={619-24}
}
High-dose busulfan is widely used in allogeneic and autologous marrow transplantation preparative regimens. Variation in the area under the concentration/time curve (AUC) for oral busulfan results in substantial risk of over or under treatment with excess risk of toxicity or relapse. Use of the IV formulation reduces this variability by eliminating variability in absorption. Variability due to drug metabolism remains, but simplified pharmacokinetic study may be employed to achieve a specific… CONTINUE READING