A limited sampling strategy for estimating individual pharmacokinetic parameters of coagulation factor VIII in patients with hemophilia A.

@article{BolonLarger2007ALS,
  title={A limited sampling strategy for estimating individual pharmacokinetic parameters of coagulation factor VIII in patients with hemophilia A.},
  author={Magali Bolon-Larger and Val{\'e}rie Chamouard and Françoise Bressolle and Roselyne Boulieu},
  journal={Therapeutic drug monitoring},
  year={2007},
  volume={29 1},
  pages={20-6}
}
Therapeutic drug monitoring of factor VIII is well established in the treatment of patients with hemophilia attributable to important interindividual variability. The individual initial factor VIII dosage is usually calculated according to individual pharmacokinetic parameters obtained after a dose test administered before the surgery, using at least five-concentration data. The authors proposed a limited sampling strategy to estimate individual pharmacokinetic parameters from one- or two… CONTINUE READING

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