A limited role for balancing selection.

  title={A limited role for balancing selection.},
  author={Saurabh Asthana and Steffen Schmidt and Shamil R. Sunyaev},
  journal={Trends in genetics : TIG},
  volume={21 1},
Balancing selection has been shown to act on several genes in short-term evolutionary contexts, but it is not known whether this force is responsible for maintaining a significant number of long-term polymorphisms. We aligned 7628 chimpanzee virtual transcripts and 5524 chimp ESTs to the 4x chimp draft genome assembly and identified polymorphisms in chimpanzee that also occurred in the human single nucleotide polymorphism database (dbSNP). Our analysis suggests that the incidence of ancestral… CONTINUE READING

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