A limited arthritic model for chronic pain studies in the rat

@article{Butler1992ALA,
  title={A limited arthritic model for chronic pain studies in the rat},
  author={Stephen Hugh Butler and Françoise Godefroy and Jean-marie Besson and Jeanne Weil-Fugazza},
  journal={Pain},
  year={1992},
  volume={48},
  pages={73-81}
}
Freund's adjuvant induced polyarthritis in rats has been used extensively to study pain processes of long duration. There are limitations of this model for chronic studies of pain/arthritis since the severe systemic changes provoke ethical concerns and also affect behaviour, physiology and biochemistry. Attempts to limit adjuvant-induced arthritis by plantar injection of the inoculum have been made. In this model, however, the process evolved to produce widespread polyarthritis if followed for… CONTINUE READING
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