A likelihood framework to measure horizontal gene transfer.
@article{Linz2007ALF,
title={A likelihood framework to measure horizontal gene transfer.},
author={Simone Linz and Achim Radtke and Arndt von Haeseler},
journal={Molecular biology and evolution},
year={2007},
volume={24 6},
pages={
1312-9
}
}We suggest a likelihood-based approach to estimate an overall rate of horizontal gene transfer (HGT) in a simplified setting. To this end, we assume that the number of occurring HGT events within a given time interval follows a Poisson process. To obtain estimates for the rate of HGT, we simulate the distribution of tree topologies for different numbers of HGT events on a clocklike species tree. Using these simulated distributions, we estimate an HGT rate for a collection of gene trees…
42 Citations
Composition-based methods to identify horizontal gene transfer.
- BiologyMethods in molecular biology
- 2009
A simple theoretical analysis based on the in silico artificial addition of known foreign genes from different prokaryotic groups into the genome of Escherichia coli K12 MG1655 shows that this organism has undergone a rather significant amount of HGT, several of which have well-defined functions that appear to be involved in the direct interaction of the organisms with their environment.
Species Trees are Recoverable from Unrooted Gene Tree Topologies Under a Constant Rate of Horizontal Gene Transfer
- Biology
- 2015
It is shown that a species phylogeny can be reconstructed correctly from gene trees even when, on each gene, each edge of the species tree has a constant probability of being the location of an HGT event.
Bayesian phylogenetic modelling of lateral gene transfers
- Biology
- 2015
A related hierarchical Bayesian phylogenetic model for reconstructing phylogenetic trees is described which imposes a temporal constraint on LGTs, namely that they can only occur between species which exist concurrently, without explicitly modelling divergence times.
Species Trees from Gene Trees Despite a High Rate of Lateral Genetic Transfer: A Tight Bound (Extended Abstract)
- BiologySODA
- 2016
It is shown that the species phylogeny can be reconstructed perfectly even when each edge of the tree has a constant probability of being the location of an LGT event, and a new reconstruction algorithm builds the tree recursively from the leaves.
Identifying a species tree subject to random lateral gene transfer.
- BiologyJournal of theoretical biology
- 2013
Using Trees to Capture Reticulate Evolution
- Biology, Computer Science
- 2009
This thesis defines a biologically sound combinatorial model for reconciliation of species and gene trees that facilitates simultaneous consideration of duplications and LGTs and defines the first probabilistic model of gene evolution incorporating a birth-death process generating duplications, LGTs, and losses, together with a relaxed molecular clock model of sequence evolution.
Phylogenomic Testing of Root Hypotheses Without a Species Tree
- Biology
- 2019
This work reformulates LCA and root inference in the framework of statistical hypothesis testing and outlines an analytical procedure to formally test competing a-priori LCA hypotheses and to infer confidence sets for the earliest speciation events in the history of a group of species.
The infinitely many genes model with horizontal gene transfer
- Biology
- 2013
The infinitely many genes model from Baumdicker, Hess and Pfaffelhuber (2010) is extended and a genealogical view is taken and a construction -- called the Ancestral Gene Transfer Graph -- of the joint genealogy of all genes in the pangenome is given.
A Bayesian Approach to Phylogenetic Networks
- Biology
- 2011
A Bayesian approach to the estimation of phylogenetic network parameters is proposed which allows for different phylogenies to be inferred at different parts of the authors' DNA alignment in the presence of reticulation events, at the species level, by using the idea that a phylogenetics network can be naturally decomposed into trees.
A Bayesian method for analyzing lateral gene transfer.
- BiologySystematic biology
- 2014
A Bayesian Markov-chain Monte Carlo-based method is presented that integrates GD, gene loss, LGT, and sequence evolution, and is applied in a genome-wide analysis of two groups of bacteria: Mollicutes and Cyanobacteria.
References
SHOWING 1-10 OF 46 REFERENCES
Stochastic Models for Horizontal Gene Transfer
- BiologyGenetics
- 2005
A simple class of stochastic models are proposed to examine HGT using multiple orthologous gene alignments and the flexibility of these models is demonstrated to test competing ideas about HGT by examining the complexity hypothesis.
The Cobweb of Life Revealed by Genome-Scale Estimates of Horizontal Gene Transfer
- BiologyPLoS biology
- 2005
Assessing the extent of HGT among core orthologous genes using a novel statistical method based on statistical comparisons of tree topology proposes that HGT events, even when relatively common, still leave the treelike history of phylogenies intact, much like cobwebs hanging from tree branches.
Ancestral genome sizes specify the minimum rate of lateral gene transfer during prokaryote evolution
- BiologyProceedings of the National Academy of Sciences
- 2007
The results indicate that among 57,670 gene families distributed across 190 sequenced genomes, at least two-thirds and probably all, have been affected by LGT at some time in their evolutionary past and a component of common ancestry nonetheless remains detectable in gene distribution patterns.
A BAYESIAN FRAMEWORK FOR THE ANALYSIS OF COSPECIATION
- BiologyEvolution; international journal of organic evolution
- 2000
A Bayesian framework for the analysis of cospeciation is developed, suggesting a simple model of host switching by a parasite on a host phylogeny in which host switching events are assumed to occur at a constant rate over the entire evolutionary history of associated hosts and parasites.
Horizontal gene transfer: A critical view
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2003
In modern organisms it is suggested that both the range and frequencies of HGT are constrained most often by selective barriers, and those HGT events that do occur most often have little influence on genome phylogeny.
Seq-Gen: an application for the Monte Carlo simulation of DNA sequence evolution along phylogenetic trees
- BiologyComput. Appl. Biosci.
- 1997
Seq-Gen is a program that will simulate the evolution of nucleotide sequences along a phylogeny, using common models of the substitution process, including the general reversible model.
From Gene Trees to Organismal Phylogeny in Prokaryotes:The Case of the γ-Proteobacteria
- BiologyPLoS biology
- 2003
The analysis indicates that single-copy orthologous genes are resistant to horizontal transfer, even in ancient bacterial groups subject to high rates of LGT, thus establishing a foundation for reconstructing the evolutionary transitions that underlie diversity in genome content and organization.
Amelioration of Bacterial Genomes: Rates of Change and Exchange
- BiologyJournal of Molecular Evolution
- 1997
Estimates of amelioration times indicate that the entire Escherichia coli chromosome contains more than 600 kb of horizontally transferred, protein-coding DNA, which predicts that the E. coli and Salmonella enterica lineages have each gained and lost more than 3 megabases of novel DNA since their divergence.
The fate of laterally transferred genes: life in the fast lane to adaptation or death.
- BiologyGenome research
- 2006
It was found that whole gene insertions/deletions in genomes occur at rates comparable to or greater than the rate of nucleotide substitution and that higher insertion/ deletion rates are often inferred to be present at the tips of the phylogeny with lower rates on more ancient interior branches.
Relationships between gene trees and species trees.
- BiologyMolecular biology and evolution
- 1988
It is well known that a phylogenetic tree (gene tree) constructed from DNA sequences for a genetic locus does not necessarily agree with the tree that represents the actual evolutionary pathway of…





