A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy.

@article{Helm2001ALA,
  title={A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy.},
  author={Gregory A. Helm and Jin Zhong Li and Tord D Alden and Susan B. A. Hudson and Elisa J Beres and Miles Cunningham and Martin Majlund Mikkelsen and Debra D. Pittman and Kelly M. Kerns and David F. Kallmes},
  journal={Journal of neurosurgery},
  year={2001},
  volume={95 2},
  pages={298-307}
}
OBJECT Bone morphogenetic proteins (BMPs) are involved in the growth and development of many tissues, but it is their role in skeletal development and their unique ability to induce ectopic and orthotopic osteogenesis that have attracted the greatest interest. Expression of the BMP-13 gene is predominantly localized to hypertrophic chondrocytes in regions of endochondral bone formation during development, as well as in mature articular cartilage in the adult. In addition, the application of BMP… CONTINUE READING

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