A lifetime cancer bioassay of quinacrine administered into the uterine horns of female rats.

@article{Cancel2010ALC,
  title={A lifetime cancer bioassay of quinacrine administered into the uterine horns of female rats.},
  author={Aida M Cancel and John E. Dillberger and Catherine M Kelly and Henry F Bolte and Dianne M. Creasy and David C. Sokal},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2010},
  volume={56 2},
  pages={156-65}
}
This study investigated if quinacrine can induce a tumorigenic response in rats when administered in a manner similar to the intended human use for female non-surgical sterilization. Young sexually mature female rats received two doses of quinacrine (or 1% methylcellulose control) into each uterine horn approximately 21 days apart, and were observed for 23 months after the second dose administration. Dose levels were 0/0, 0/0, 10/10, 70/70, and 70/250-350 mg/kg (first dose/second dose), which… CONTINUE READING